大鼠尾壳核头部生长抑素mRNA的区域性表达

REGIONAL REGIONAL DISTRIBUTION OF SOMATOSTATIN mRNA POSITIVE NEURONS IN THE HEAD OF NUCLEUS CAUDATUS PUTAMEN IN RATS

目的 观察尾壳核 (CP)头部背内侧区、背外侧区、腹内侧区和腹外侧区生长抑素 (SOM )mRNA阳性神经元分布特点。方法 采用原位杂交组织化学方法。结果 CP头部不同区域SOMmRNA阳性神经元的密度存在差异 ,腹内侧区SOMmRNA阳性神经元的密度明显高于其他区 (P <0 0 1)。结论 CP头部不同区域的SOMmRNA阳性神经元密度存在差异 ,这可能是CP头部不同区域机能差异的形态学基础之一。

Objective To observe the regional distribution of SOMmRNA positive neurons of dorsomedial, dorsolateral, ventromedial and ventrolateral areas in the head of nucleus caudatus putamen(CP)in rats. Method The method of in situ hybridization histochemistry was used. Result There were regional differences in the distribution of SOMmRNA positive neurons in the head of CP. The density of SOMmRNA positive neurons was markedly higher in the ventromedial area than in the other areas (P<0.01) . Conclusion There were differences in the regional distribution ofSOMmRNA positive neurons in the head of CPin rats. These differences may be one of the morphological bases of functional differences between the different areas in the head of CP.