心房颤动患者C反应蛋白增高的临床意义

The Significance of Elevated C-reactive Protein in Patients With Atrial Fibrillation

目的 :探讨C反应蛋白 (CRP)增高在心房颤动 (房颤 )发病中的意义。方法 :应用免疫比浊法测定 79例诊断为房颤患者血清CRP水平 ,与对照组比较 ,并对房颤按持续时间、病因不同分设亚组 ,进行统计学分析。结果 :房颤组、对照组血清CRP水平分别为 (4.30± 2 .87)、(1.15± 0 .90 )mg/L ,两组比较p <0 .0 5。器质性、孤立性性房颤者CRP水平分别为 (5 .0 6± 1.92 )、(4.37± 1.32 )mg/L ,均高于对照组 ,p <0 .0 5。持续性、永久性房颤者CRP水平分别为 (5 .6 0± 1.80 )、(5 .0 0± 1.6 0 )mg/L ,均高于阵发性房颤 (3.30± 1.2 0 )mg/L ,p <0 .0 5。 结论 :CRP增高反映的炎症状态可能促进房颤发生 ,以及呈持续发作。

Objective:To evaluated the effect of CRP increasing in pathogenesis of atrial fibrillation. Method: The immunochemistry method was used to determine the serum CRP concentration in 79 AF patients . Grouping these patients according to the lasting paroxysm of AF and pathogenetic factor. Result : Serum CRP level of patients with AF (4.30±2.87)mg/L was higher than that in control group (1.15±0.90)mg/L,p<0.05 . The CRP level of isolated AF patients were (5.06±1.92) and(4.37±1.32)mg/L ,higher than that in control group respectively , p<0.05 . serum CRP level of persistant and permanent AF (3.30±1.20)mg/L,p<0.05 . Conclusion : The inflannmatory state , reflected by the elevation of serum CRP level , may promote the occurrence and persistence of AF.