男性精神分裂症患者5-HT_(2A)受体基因T102C多态性与迟发性运动障碍的关联

T102C Polymorphism in5-HT_(2A) Receptor Gene and Tardive Dyskinesia in Chronic Schizophrenia

目的探讨5-羟色胺2A(5-HT2A)受体基因T102C多态性与精神分裂症伴迟发性运动障碍(TD)的相关性。方法用异常不自主运动量表(AIMS)评定男性精神分裂症患者;对42例符合TD(AIMS总分≥3分)者和与TD组严格相匹配的51例非TD者,采用简明精神病评定量表(BPRS)评定精神症状;应用聚合酶链反应-限制性片段长度多态性方法分析5-HT2A受体基因T102C多态性的分布频率。结果⑴经吻合度检验,TD组、非TD组的5-HT2A 受体基因T102C多态性位点的基因型分布均符合Hardy-Weinberg平衡法则(χ2分别为0.06、0.02,υ均=2,P均>0.05)⑵TD组与非TD组的基因型总体分布的差异无显著性(χ2=4.37,υ=2,P>0.05),等位基因频率分布的差异有显著性(χ2=4.36,υ=1,P<0.05)。⑶TD组的AIMS和BPRS的评分分别为(6.5±1.8)分和(51.2±7.8)分,非TD组分别为0分和(50.3±7.4)分,差异无显著性(P>0.05)。结论5-HT2A受体基因的T102C多态性可能与男性精神分裂症患者的TD相关联。

Objective:The present study was to investigate whether the genetics variation of the serotonin 2A(5-HT2A)receptor gene was associated with tardive dyskinesia(TD)in chronic schizophrenic patients receiving long-time typical antipsychotics. Methods: 42 male schizophrenic Patients with TD, 51 without TD were entered the study. The diagnosis of TD was made according to the Abnormal Involuntary Movement Scale(AIMS) score, with the AIMS score≥3 as having TD. Psychiatric symptoms were rated using the Brief Psychiatric Rating Scale(BPRS).The 5-HT2A receptor gene polymorphism was analyzed with the polymerase chain reaction-restriction fragment length polymorphism. Results:⑴The distributions of genotypes in patients with TD or without TD all followed Hardy-Weinberg law(χ 2 =0.06?0.02,allυ=2,all p>0.05).⑵There were no significant differences of genotypic distribution between the TD group and the without TD group (χ 2 =4.37,υ=2,p>0.05). A significant excess of C allele was in patients with TD compared to those without TD(χ 2 =4.36,υ=1,p<0.05).⑶There were no significant differences in clinical demographic characteristics and scores of clinical assessment between the patients with TD and those without TD (p>0.05). Conclusion:Our result suggest that the T102C polymorphism in 5-HT2A receptor gene may be association with TD in chronic male schizophrenic patients