血清TpP、hs-CRP、CKMB、cTnI在急性心肌梗死中的诊断意义

Value of Measuring TpP,hs-CRP,CKMB and cTnI in Patients With Acute Myocardial Infarction

目的探讨血栓前体蛋白(TpP)、高敏C反应蛋白(hs-CRP)、肌酸激酶同工酶(CKMB)及心肌肌钙蛋白I(cTnI)联合检测在急性心肌梗死(AMI)中的诊断价值。方法 测定26例急性心肌梗死患者胸痛发作6小时内及24小时TpP、hs-CRP、CKMB及cTnI。结果AMI胸痛发作6小时内TpP的敏感性最高,发病6小时后hs-CRP、CKMB及cTnI显著升高,cTnI阳性持续时间长,而hs-CRP在AMI时可出现明显升高。结论TpP对于AMI具有早期诊断价值,cTnI与hs-CRP、CKMB一起相互补充,具有重要的临床诊断及判断预后的意义。

Objective To investigate the value of measuring thrombus precursor protein(TpP),high-sensitivity C-reactive protein(hs-CRP),creatine kinase MB(CKMB) and cardiac troponinI(cTnI) in patients with acute mycardial infarction. Methods TpP ,hs-CRP , CKMB and cTnI were measured in 26 patients with acute mycardial infarction within 6 hours and at 24 hours after the onset of symptoms. Results Significantly abnormal concentrations of TpP were observed in the patients within 6 hours after the onset of symptoms ,and the others were observed after the onset 6 hours later. The times of cTnI positive rate is long. The hs-CRP increased significantly in AMI. Conclusion TpP can be used as a diagnostic parameter for early AMI.The measure of blood cTnI,hs-CRP,CKMB are a better predicting index for AMI.