摘要
最近的研究表明,rtPA引起的出血性转化与基质金属蛋白酶 9(MMP 9)关系密切。血液或脑 脊液MMP 9水平增高预示脑梗死灶将发生出血性转化,MMP 9抑制剂有望降低rtPA引起的脑梗死 出血性转化的发生率。增强MRI和弥散加权磁共振成像(DWI)等上的血脑屏障破坏和其他改变,可 预测出血性转化。
The recent studies have suggested that there are close correlations between the hemorrhagic transformation caused by recombinant tissue plasmonigen activator (rtPA) and matrix metalloproteinases-9 (MMP-9). The increase of the levels of MMP-9 both in blood and cerebrospinal fluid predicts subsequent hemorrhagic transformation in cerebral infarction. MMP-9 inhibitors are expected to reduce the incidence of rtPA-induced hemorrhagic transformation in cerebral infarction. Blood-brain barrier disruption and other changes on enhanced magnetic resonance imaging and diffusion-weighted imaging may predict the hemorrhagic transformation.
出处
《国外医学（脑血管疾病分册）》
2004年第12期907-910,共4页
Foreign Medical Sciences Cerebrovascular Diseases
