宽胸丹治疗痰瘀阻滞型胸痹(冠心病心绞痛)临床观察

Clinical Observation on Obstruction of Qi in the Chest due to Stagnation of Phlegm-stasis ( Angina Pectoris Owing to Coronary Heart Disease) Treated by Kuanxiong Dan

目的 :观察宽胸丹治疗痰瘀阻滞型胸痹 (冠心病心绞痛 )的临床疗效及作用机制。方法 :选择胸痹 (冠心病心绞痛 )患者6 0例 ,采用单盲法随机分为两组 ,宽胸丹 4 0例和地奥心血康 2 0例 ,分别予以宽胸丹和地奥心血康治疗 2 0d。结果 :宽胸丹组和地奥心血康组对心绞痛改善有效率分别为 90 %和 6 0 % ,两者相比较具有显著性差异 (P <0 .0 5 ) ;对心电图有效率分别为6 3.9%和 33.3% ,两者比较有统计学意义 (P <0 .0 5 ) ,两组对硝酸甘油停减率的影响无显著性差异 (P >0 .0 5 )。宽胸丹能明显降低患者TC、TG、LDL -C值 ,升高HDL -C值 ,两组对血脂异常的有效率分别为 84 .2 1%和 5 5 .5 5 % ,并能明显降低血浆ET - 1含量 ,与地奥心血康组比较有显著性差异 (P <0 .0 5或P <0 .0 1)。结论 :宽胸丹在改善胸痹心绞痛临床症状、心电图方面具有较好疗效 ,并且能明显降低ET - 1水平 ,降低TC、TG、LDL -C值、升高HDL -C值 ,具有防治动脉粥样硬化的作用。

Objective: To observe the clinical therapeutic effectiveness and mechanism of Kuanxiong Dan in treating obstruction of qi in the chest due to stagnation of phlegm-stasis (angina pectoris owing to coronary heart disease). Methods: 60 cases of patients with obstruction of qi in the chest were randormly divided into Kuanxiong Dan Group (40 cases) and Diao Xinxue Kang Group (20 cases). Two groups were treated respectively by Kuanxiong Dan and Di'ao Xinxue Kang for 20 days. Results: Kuanxiong Dan Group and Di'ao Xinxue Kang Group respectively had 90% and 60% of effective rates, there was significant difference between two groups (P<0.05). As to the electrocardiogram, two groups respectively had 63.9% and 33.3% of effective rates, there were statistical meaning (P<0.05). As for the influence on the withdrawal and decreasing rate of nitroglycerin, there was no significant difference (P<0.05). Kuanxiong Dan evidently decreased patient's figure of TC, TG, LDL-C and increased the HDL-C figure. As to the nomal blood-lipid, two groups respectively had 84.21% and 55.55% of effective rate and decreased evidently the ET-1 content of blood plasma. Therefore there was significant difference (P<0.05 or P<0.01) between two groups. Conclusion: Kuanxiong Dan has a much bette therapeutic effectiveness in improving the clinical effectiveness in improving the clinical symptoms of obstruction of qi in the chest (angina pectoris owing to coronary heart disease) and electrocardiogram. And it can remarkably decrease the ET-1 level and patient's figure of TC, TG, LDL-C and increase the HDL-C figure. And it also has the function of preventing and treating atheroscleorsis.