益气活血法治疗早期糖尿病肾病36例疗效观察

Therapeutic Observation on Therapy of Supplementing qi and Activating Blood Circulation for 36 Cases of Early Diabetic Nephrosis

目的 :观察益气活血法治疗早期糖尿病肾病 (DN)的临床疗效。方法 :将 72例DN患者随机分为治疗组和对照组各 36例 ,分别给予糖适平 90～ 180mg/d或达美康 16 0～ 32 0mg/d口服。治疗组在此基础上服用益气活血之中药。结果 :治疗组临床有效率为 88.89% ,对照组为 6 1.11% ;两组治疗前后空腹血糖 (FBG)、糖基化血红蛋白 (HbA1C)、尿蛋白排泄率 (UAER、尿β2 微球蛋白Uβ2 -MG)等指标的改善 ,治疗组优于对照组 ,其中全血黏度低切、高切两组比较 ,差异有显著性 (P <0 .0 5或P <0 .0 1)。结论 :益气活血法是治疗早期糖尿病肾病的一种较为理想的方法。

Objective: To observe the therapeutic effectiveness of therapy of supplementing qi and activating blood circulation for early diabetic nephrosis. Method: 72 caese of diabetic nephrosis were randomly divided into the treated group and the controlled group. Two groups took orally Tang Shiping 90～180 mg/d and Da Meikang 160～320 mg/d respectively. The treated group, in addition to the above administration, were given Chinese herbs with the nature of supplementing qi and activating blood circulation. Results: The treated group had 88.89% of effective rate while the controlled group 61.11%. The treated group is better than the controlled group in the index promotion of fasting blood-glucose (FBG), glycosylation hemoglobin (HbAc), Ruinary protein excretory rate (UAER), Urinary β 2 micro globulins(Uβ 2-MG). Two groups had a remarkable difference (P<0.05 or P<0.01) compared with each other in the hight cut and low cut of whole blood viscosity. Conclusion: Therapy of supplementing qi and activating blood circulation is ideal for treating early diabetic nephrosis.