不同发病年龄的老年期情感障碍的临床差异

The clinical differences of patients with affective disorder in geratic period

研究目的探讨老年期情感障碍的临床特征,比较不同发病年龄的老年期情感障碍临床各方面的差异。研究背景以初发年龄60岁为界,将老年期情感障碍分为老年前期和老年期情感障碍,这两种情形在临床是否各有特征,目前研究尚少。研究方法 1.13例按发病年龄,以60岁为界分两组,从临床各角度总结其发生率,取γ~Z检验两组间的差异是否存在。研究结果老年组单相抑郁和性格内向者均显著高于老年前期组(P<0.01),老年组躯体症状和治疗副反应率也均高于老年前期组(P<0.05),单相抑郁病期老年组为36.2±27.69周,老年前期组为17.21±5.47周,发病缓起及自杀倾向者老年组较老年前期组多见。结论老年期情感障碍症状多不典型;60岁以前发病与60岁以后发病的老年期情感障碍在临床许多方面有差异,提示老年期情感障碍有异源性特征。

Objective To research for the clinical char-acteristics and differences of the patients withaffective disorder in geratic period,the presentstudy is performed. Background The clinical characteristics ofaffective disorder in geratic period have been re-ported.It is not determined that whether there isdjfference of clinical features of affective disorderbetween geratic period and presenium,and studiedwithfewforit. ’ Methods All of 1 1 3 patients with affectivedisorder in geratic period was separated into twogroups,by onset age and as boundary as onsetbefor and after 60 old years.The incidence of theclinical aspects was calculated,and statistics werehandled with Chi-Squre test. Results The incidences of uniphase depres-sion(63％),introvert(63％)in geratic periodwere high than that of presenium remarkably(P<0.0 1,respectively),the somatization symp.toms and incidence of side-effects in geratic peri—od than that of presenium (P<0.05,respectively).The mesan stadia of uniphase de—pression in geratic depression(36.2±27.69W)were more than that of pressenium f 1 7.21±5.47W,P<0.05).The delayed type and suic suicid behavior were more in geratic period thanpresenium patients. Conclusion There are clinical differences of affective disorder between geratic period andpresenium onset.