摘要
75例海洛因成瘾者,男57例,女18例;平均年龄25.4±1.8a。50例用二氢埃托啡225-600μg/d,平均286±15μg/d,25例用美沙酮10-20mg/d(平均15.3±2.5mg/d)对照,用药7-10d,治疗前后比较,对解除阿片戒断症状疗效显著,P<0.01,说明二氢埃托啡与美沙酮疗效一致,副作用轻微,提示该药物在正确使用下可作为海洛因成瘾者脱瘾药物。
Seventy-five patients (M 57, F 18, age 25.4 ?1.8 a) with heroinomania were equally divided into 3 groups:A) sl and iv gtt dihydroetorphine (DHE) 225-600 ft g/d (286 ?15 g/d); B) the same dose of DHE and po chlorpromazine 25-50 mg/d; C) po methadone 10-20 mg/d (15.3 + 2.5 mg/d). Courses of therapy were 7-10 d. Using Hamilton rating scale for depression to evaluate the abstinence symptom. Results revealed that DHE had a marked effect in eliminating opium abstinence symptom (P <0. 001). Its effect was as good as that of methadone. Their adverse reactions were mild. After treatment sc 0.4-0.8 mg naloxone is given, and simultaneous analysis of urine for the narcotic is performed. Negative results of these two tests were obtained in all 50 patients.
出处
《新药与临床》
CSCD
北大核心
1993年第1期27-30,共4页
关键词
二氢埃托啡
治疗应用
海洛因
成瘾
dihydroetorphine/therapeutic use: methadone/therapeutic use
heroin dependence
substance withdrawal syndrome
