卡托普利与地高辛治疗充血性心力衰竭的疗效对比

Comparison of the therapeutic effect between captopril and digoxin in congestive heart failure

充血性心力衰竭患者65例(男性42例,女性23例;年龄58±9a),其中33例用卡托普利25-50mg, po, tid;32例用地高辛0.125-0.25mg,bid-fid;症状控制后减量均治疗4-12wk。结果:总有效率前者为91％,后者为78％;左室泵功能指标(FS, EF, SI, CI)2组均显著改善(P<0.01);左室舒张功能指标(A峰,A/E, AI/TVI, PFR, NPFR)前者显著改善,(P<0.01),后者无变化(P>0.05)。

Among sixty-five patients with congestive heart failure (M 42, F23;age 58 ?9a), 33 patients were treated with po captopril 25-50 mg tid, and 32 patients were treated with po digoxin 0,125-0.25 mg bid-tid; the dosage was decreased when the symptoms were controlled, all for 4-12 wk. Results showed that total response rate were 91 % and 78 %, respectively. Cardiac function were assessed by two-dimensional pulse echocardiography. Left ventricular systolic function parameters (FS, EF, SI, CI)in both groups were improved (P<0. 01). The left ventricular diastolic function parameters (peak A, A/E ratio, AI/TVI ratio, PFR, NPFR) in the captopril group were also improved (P<0. 01), but not in the digoxin group (P>0. 05).