阿普唑仑治疗社交恐怖症的双盲自身对照

Alprazolam therapy for phobia: a double-blind trial

阿普唑仑与安慰剂双盲自身对照治疗社交恐怖症16例(男性6,女性10;平均年龄23±5a),剂量为3.2mg/d,疗程4wk,以Marks的恐怖强迫量表为评定工具,按双向序贯t检验逐个观察。至第10例时便获得结论,阿普唑仑的疗效显著优于安慰剂,且未发现明显的副作用。

Sixteen social phobia (M6,F10; age 23±5a)were given alprazolam or placebo in a selfcon-trolled double-blind trial. Each patient received a daily dose of 3.2mg for 4 wk and their symptoms were assessed with MSCPOR before and after the treatment.These patients were observed one by one by the method of the two-sided sequential t test. While finishing the tenth patient, the results showed that alprazolam had significant effects than the control group. No apparent adverse reactions were noted.