藻酸双酯钠治疗糖尿病性周围神经病变

Treatment of diabetic peripheral neuropathies with polysaccharide sulfate

糖尿病周围神经病变55例,其中30例(男性19例,女性11例;年龄52±s 8a)采用藻酸双酯钠(PSS)0.1g, tid, po,共治疗90d。另25例(男性16例,女性9例;年龄53±8a)采用维生素B_1和(或)阿司匹林常规剂量口服为常规组,疗程同上。结果:PSS组起效快(3-10d),症状及浅感觉的改善非常显著,肌腱反射较慢,总有效率为97％。常规组起效慢(>10d),而症状、浅感觉及肌腱反射改善均较慢,总有效率为80％,2组差别有显著意义(P<0.05)。

Fifty five patients with diabetic peripheral neuropathies were divided into two groups. Thirty patients(M 19, F 11; age 52 ± 8 a)received polysaccharide sulfate(PSS) 0.1 g, tid, po,X90 d. Twenty five patients(M 16, F9; age 53 ± 8 a)received one or two kinds of vitamin B1 20 mg, or aspirin as regular group, po, X 90 d, as controls. Results revealed that the effect was fast(3-10 d), symptoms, superficial sensation improved obviously, tendon reflexes improved slowly with total response rate 97% in PSS group; but that of control group was slow( p> 10 d), symptoms, superficial sensation, tendon reflexes improved slowly with total response rate 80%. There was a significant difference of the two groups(P< 0.05).