卡托普利对冠心病左室舒张功能的影响

Effects of captopril on left ventricular diastolic function in patients with coronary heart disease

17例冠心病患者(男性12例,女性5例,平均56±6a)采用多普勒血流图,在用卡托普利12.5mg, tid, po×4wk,测定治疗前后左室舒张功能参数,并作对比。治疗4wk后,在心绞痛组,E峰增加,A峰下降,DC增快;在心肌梗死组,A峰与DC均无明显变化。提示卡托普利可改善左室舒张功能。此外,该药可降低血压,但心率变化不大。

The left ventricular diastolic function of 17 coronary heart disease patients (M 12, F 5;age 56 ± 6a) before and after captopril (12. 5 mg, tid, f>o, 4 wk) were compared using pulse Doppler echocar-diography mitral flow. Before treatment, the patients manifested low PE waves, high PA waves, high PA/PE ratio, and slowed deceleration rates. After treatment, the PE wave increased, PA wave reduced, deceleration rate increased in angina pectoris group, but did not change much in myocardial infarction group. Systolic, diastolic and mean blood pressure were all reduced. It is concluded that captopril may reduce blood pressure, decrease cardiac oxygen consumption and improve left ventricular diastolic function, which is beneficial to the coronary heart disease patients.