美托洛尔与维拉帕米治疗阵发性室上性心动过速的比较

Comparison between metoprolol and verapamil on patients with paroxysmal supraventricular tachycardia

阵发性室上性心动过速患者40例,分为2组。美托洛尔组21例,用酒石酸美托洛尔2.5mg或5mg加入葡萄糖液10mL或20mL,以2mL/min速度静脉注入,间隔5-10min可重复注射,心电图监护下俟转为窦性心律即停药,总量<10mg。维拉帕米组19例,用维拉帕米5mg加葡萄糖液10mL,静注速度、方法、总量同上。有效率分别为81％和74％(P>0.05);平均起效时间分别为16±11min和9±9min(P<0.05)。

Forty patients with paroxysmal supraventricular tachycardia were randomly divided into 2 groups. Twenty-one patients were treated with metoprolol tartrate 2.5 mg or 5 mg in 10 mL or 20 mL glucose solution, given at 2 mL/min, iv and repeated after 5-10 min, the patients were monitored with electroeardiography, the medication was slopped as soon as the sinus rhythm was recovered, the. total dose was less than 10 mg. Nineteen patients were treated with verapamil in 10 mL glucose solution, the infusion rate, method, and total dose were same as those for metoprolol. Results revealed that the response rates were 81% and 74% (P>0.05) and average initialling times were 16+11 min and 9 + 9 min (P < 0. 05), respectively.