钙调素的分子识别研究进展

Progress in molecular recognition of calmodulin

钙调素 (CaM ) ,作为细胞内Ca2 + 信号传导途径中的主要信号转导分子 ,普遍存在于真核细胞中 ,介导调控由Ca2 + 引起的一系列生理生化反应 ,参与并调节细胞的增生、分化、运动等基本代谢过程。对CaM的结构及分子识别机制的研究 ,有助于更好地理解细胞信号传导、蛋白质相互作用的分子机制 ,对新药开发和临床治疗具有重要的指导意义。本文作者就近几年来有关CaM结构及分子识别机制的研究现状作一概述。

Calmodulin(CaM),as major intracellular Ca 2+ signal transductor,is a ubiquitous, multifunctional protein in eukaryotic cells,invovled in a wide variety of cellular processes . Study of the structure and molecular recognition mechanism of CaM helps better understanding intracellular Ca 2+ signaling system and molecular recognition of protein-protein interaction,giving new insight into medicine development and clinical therapy. This paper reviews progress in the studies of molecular recognition of calmodulin in recent past years.