核因子kappa B与体外循环相关性的研究进展

Research progress of correlation between NF-κB and CPB

核因子kappaB(NF κB)是许多促炎因子高表达所必需的转录因子。近年来 ,随着分子生物学技术的发展 ,NF κB对免疫、应激和炎症反应以及淋巴细胞分化和生长的调控作用成为研究的热点。作者就NF κB在缺血 再灌注及体外循环损伤机制中的作用作一综述 ,并简要介绍阻断NF κB激活干预治疗的研究进展。

Nuclear factor kappa B(NF-κB) is an important transcription factor in the expression of many inflammatory media. With the recent progress of molecular biological technique, the modulated mechanism of NF-κB in immunity, stress, inflammatory responses, and the differentiation and growth of lymphocyte has been the focus. This review presents the role of NF-κB in ischemia-reperfusion and cardiopulmonary bypass, and the research progression of intervention therapy in inhibition of the activation of NF-κB is also introduced herein after.