红芪对油酸型肺损伤大鼠肺泡－动脉血氧分区差和气－血屏障变化的影响　

Effects of Redix Hedysari on Changes of Alveolar-arterial Oxygen Gradientand Blood-air Barrier in Rats with Respiratory Distress Syndrome

本文应用血气分析仪测定分析了红芪对油酸致肺损伤大鼠Ｐ（Ａ－ａ）ＤＯ２变化的影响，应用电子显微镜观察了其气－血屏障超微结构的变化。结果：红芪能减少油酸型ＲＤＳ大鼠Ｐ（Ａ－ａ）ＤＯ２，维持肺有效的摄氧功能；能保护肺泡上皮细胞和毛细血管内皮细胞，使气体通过气－血屏障的弥散基本正常。本文为红芪治疗ＲＤＳ提供了理论依据。

ith blood-gas analysis instrument and electronic microscope. effects of Redix Hedysari on changes ofAlveolar-arterial oxygen gradient [P(A-a)DO) and blood-air barrier in rats with experimental respiratory distress syndrome (RDS) induced by oleic acid were observed. The results showed that Hedysari could reduce P(A-a)DO in RDSo f rats .maintaining the assimilating function of the lung .and protect the pulmonary alveolar cell and capillary epithelium cell. remaining normal structure of the bind-air barrier. The present study provided scientific proof for the treatment of Hedysari on RDS.