摘要
微粒体甘油三酯转运蛋白MTP(microsomaltriglyceridetransferprotein ,MTP)首先是从牛的肝细胞微粒体碎片中分离获得的 ,其作用是加速甘油三脂 (triglyceride ,TG)、胆固醇 (cholesterylester ,CE)和磷脂酰胆碱 (phos phatidylcholine ,PC)的转运和细胞或亚细胞膜的生物合成。它后来在肝细胞和小肠的微粒体膜中发现[1 ] ,由于它的位置及其转运TG可以推测与血浆脂蛋白中极低密度脂蛋白 (verylowdensitylipoprotein ,VLDL)和乳糜微粒 (chylomi crons ,CM)的组装过程有关。
The microsomal triglyceride transfer protein (MTP) which was originally isolated from the microsomal fraction of bovine liver , accelerates the transport of triglyceride(TG), cholesteryl ester (CE) and phosphatidylcholine (PC) between synthetic membranes. The protein was subsequently found within the lumen of microsomes isolated from both liver and intestine. The tissue distribution with its ability to transport TG , led to the hypothesis that MTP is involved in the assembly of plasma lipoprotein , very low density lipoprotein (VLDL)and chylomicrons (CM ).
出处
《生物技术通报》
CAS
CSCD
2005年第1期16-19,共4页
Biotechnology Bulletin
