416例献血者和291例病毒性肝炎患者丙型肝炎病毒抗体的调查

DETECTION OF ANTIBODY AGAINST HEPATITIS C VIRUS ( HCV ) IN 416 BLOOD DONORS AND 291 PATIENTS WITH VIRAL HEPATITIS

用ELISA法对某市及附近地区的416例献血员和271例病毒性肝炎患者、17例肝硬化和3例肝癌患者作了血清抗-HCV检测。结果发现120名志愿献血者全部阴性。235名职业供全血者中,阳性25名,阳性率为10.64％。61名职业供血浆者中,阳性18名,阳性率为29.51％。输血后肝炎(PTH)21例,全部阳性。慢性乙型肝炎250例,5例阳性,阳性率为2％。肝硬化17例,2例阳性,阳性率为11.2％。重症肝炎及肝癌各3例,均为阴性。检测结果提示在职业献血员中,HCV感染率较高,是造成PTH的主要原因,应积极开展检测预防,不容忽视;而慢性肝炎、肝硬化的发生与HCV感染有一定关系。

Many blood donors and patients with viral hepatitis , cirrhosis of liver ( LC ) or hepatocytic cancer ( HCG ) in a city and its nearby regions were investigated for serum anti-HCV by ELISA using anti-HCV EIA kit supplied by the Institute of Liver Disease of Beijing Medical University. It was fou-nd that all of the 120 volunteer blood donors were anti-HCV negative . But 25 out of the 235 ( 10.64% ) professional whole blood donors and 18 out of the 61 (29.5% ) professional blood plasma donors were positive. AH of the 21 ( 100%' ) cases of post-transfusion hepatitis ( PTH ) were positive . 5 of the 250 ( 2 % ) cases of chronic hepatitis B ( CHB )' and 2 of the 17 ( 11.2% ) cases of HBVM positive LC were positive. The 3 cases of fulmi-nat hepatitis ( FH ) and 3 cases of HCC were all negative. These observations suggest that the high incidence of HCV infection in professional blood donors is the main cause of PTH, and therefore, efforts should be made to detect and prevent HCV infection. Besides, the occurance of CHB and LC is believed to be related to HCV infection.