实验性雏鸡佝偻病的病理学研究——Ⅱ.形态学观察

PATHOLOGICAL STUDIES ON EXPERIMENTAL RICKETS IN BROILER CHICKENS II. MORPHOLOGICAL OBSERVATIONS

4日龄 Aiboi Acies肉鸡健雏80只随机分为4组,分别喂给钙-磷缺乏(Ca 0.02％,P0.30％)、缺钙(Ca 0.02％,PO.71％)、缺磷(Ca 0.95％,PO.30％)和正常对照(Ca 0.95％PO.71％)日粮三周,进行了系统的病理形态学观察。缺磷组病变表现为肋骨头肿大,长骨骨骺生长板之肥大带明显增宽,骨小梁减少;缺钙组和钙-磷缺乏组病变表现为肋骨增粗弯曲,长骨骨骺生长板之增生带显著增宽,海绵骨类骨组织和结缔组织大量增生,成骨细胞和破骨细胞丰富。结果表明,钙缺乏和磷缺乏所致病变显著不同,为鉴别诊断提供了科学依据。

Eighty 4-day-old Aiboi Acies brolier chickens were divided into 4 groups, and fed on diets as follow: 1. Ca-P deficient (Ca 0.02%, P 0.30%), 2. Ca deficient (Ca 0.02, P 0.71%), 3. P deficient(Ca0.95%, P 0.30%), and 4. controls (Ca 0.95%, P 0.71%) for 3 weeks. In groups 1 and 2, the ribs were thickened and crooked at necropsy. The proliferating zone of the growth-plate in the epiphysis of the long bone was lengthened and irregular. A lot of osteoid and fiborus tissue, and abundant osteoclasts and osteob-lasts appeared in the metaphyseal spongiosa histopathologically. Group 3 showed enlarg-ment at the caput costae grossly, and length of the hypertrophic zone of the growth-plate in the long bone. The osseous trabeculae in the metaphyseal spongiosa were reduced. Results demonstrated that the rachitic lesions produced by calicium deficiency were very different from those of phosphorus deficiency. The differential diagnosis between group 1 and group 2 was also discussed in the paper.