喹乙醇在鸡体内的药物动力学及组织浓度研究

STUDIES ON PHARMACOKINETICS AND TISSUE CONCENTRATION OF OLAQUINDOX IN CHICKENS

本文对24只健康石岐杂中鸡单剂量内服(30mg/kg)和静注(20mg/kg)喹乙醇作了药动学分析,对32只健康石岐杂中鸡单剂量内服喹乙醇(30mg/kg)作了组织浓度测定。用高效液相色谱法测定不同时间血浆和组织的药物浓度。喹乙醇静注给药后的血药浓度——时间数据用房室分析法、内服给药后的血药浓度——时间数据用统计矩理论非房室分析法处理。经计算所得的主要动力学参数如下,内服:t1/2 ka 0.64±0.10h,t1/2 ke 1.25±0.06h,AUC_(po) 68.84±3.12mg/L·h;静注:t1/2α 0.27±0.02h,t1/2β 1.72±0.03h,Vd 0.56±0.05L/kg,CL_B 0.23±0.01L/kg/h,AUC_(iv) 87.20±1.58mg/L·h。生物利用度F为52.99±2.32％。组织浓度测定结果表明,喹乙醇在肌肉、肝、肾、脾、肺的浓度较低,给药后24小时,这五种组织中喹乙醇的残留已低于检测限(0.2μg/g)。喹乙醇在鸡体内的吸收、分布、消除均迅速。

Twenty four healthy adult chickens were used to study the pharmacokinetics of olaquindox by oral (30mg/kg) and intraveneous (20mg/kg) administration. The tissue concentrations in muscle, liver, kidney, spleen and lung were studied after oral administration (30mg/kg) in 32 healthy adult chickens. The levels of olaquindox in plasma and tissues were determined by HPLC. the drug concentration-time data in plasma following single intraveneous injection were analysed with MCPKP program and the blood drug concentration-time data after oral administration were analysed by noncompartment analysis based on statistic momment theory. Pharmacokinetic characteristics following single intraveneous injection were described by a two-compartment open model. The pharmacokinetic parameters of olaquindox in chickens are as follows: oral-t1/2ka, 0.64± 0.l0h, t1/2ke 1.25±0.06h, AUCpo 68.84±3.12mg/L·h; intraveneous-t1/2a 0.27±0.02h, t1/2 1.72±0.03h, Vd 0.56±0.05L/kg, CLB 0.23±0.01L/kg·h-1 AUCiv 87.20+1.58 mg/L·h. F 52.99±2.32%. The concentrations of olaquindox in the five tissues were rather low and they were not detectable after 24 hours of administration, i. e., lower than the limit of detection. Among the five tissues, the concentration in musle was the highest (2.61μg tissue). The absorption, distribution and elimination of plaquindox in chickens were very rapid at the dose used.