马麻醉综合监测的研究

STUDIES ON THE COMPREHENSIVE MONITORING OF ANESTHESIA IN THE HORSE

本实验以心电图、心音图、心阻抗血流图、心阻抗微分图、血气、脑电图等作为监测手段,对10匹实验马静松灵、水合氯醛、激光三种麻醉方法实验前和实验后10、30、60、90、120分钟(水合氯醛还包括150分钟和180分钟)进行了比较观察。结果表明,在一般临床检查和常规监测还没有出现明显的临床体征之前,动物的HR、SV、CO、CO/kg、PO_2、Sat·O_2、、P_A-aDO_2pH和脑电图等参数已发生了明显的变化,说明这些特殊监测方法更敏感、更准确。本实验首次在兽医临床开展了麻醉综合监测的研究,并建立了马麻醉综合监测的实验模型。

Ten healthy adult horses were anesthetized with three medthods including Jing-Song-Ling, Choloral hydrate and the Laser beam respectively, and the responses were monitored with model SJ-42 polygraphy, model DH-100G blood gas and acid-base analyzer, the important parameters were obtained through the special instrument monitoring with electrocardiongram (ECG), phonocardiogram (PCG), impedance cardiogram (ICG), first derivative-gram (FDG), blood gas, electroencephalogram (EEG) and some routine monitoring items in the recumbent healthy horses. The changes in the above-mentioned items before, during and after anesthesia were observed comprehensively and a large quantity of data obtained laid down a solid foundation for further studies in the same field and established a model for the comprehensivce monitoring of anesthesia in the horse. The results indicated that Jing-Song-Ling and Choloral hydrate both had influence on the cardiac function and blood gases, Jing-Song-Ling caused a remarkable decrease in the CO, CO/kg, Po2 and Sat·O2, and Choloral hydratq caused remarkable decrease in the SV、 Po2、 Sat·02、 in the horses. As a general rule, the choloral hydrate took effect more quickly than the Jing-Song-Ling after injection, and the same matter happened during recovering. However, both drugs decreased the frequency and increased the amplitude of the EEG, leading to an activity of low frequency and high amplitude. While the laser beam had no effect on the parameters of cardiac function and blood gas, it did cause a remarkably decreasing frequency in the EEG though the changes were not as significant as those caused by Choloral hydrate and Jing-Song-Ling. These data are important in the selection of proper methods and drugs for anesthesia in both researches and clinical practice.