摘要
An oil-in-water (O/W) solvent evaporation method was used to prepare biodegradable microspheresbased on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, was chosen as a model molecule in the studyof drug entrapment and release. Effect of preparation conditions on the size, morphology, drug loading, and releaseprofiles of micropheres was investigated. Based on in vitro release experimental findings, a diffusion/dissolutionmodel was presented for quantitative description of the resulting release behaviors and drug release kinetics fromPLA microspheres analyzed. The mathematical models were used to predict the effect of microstructure on theresulting drug release. It provided an approach to determine the suitable structure parameters for microspheres toachieve desired drug release behaviors.
An oil-in-water (O/W) solvent evaporation method was used to preparebiodegradable microspheres based on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, waschosen as a model molecule in the study of drug entrapment and release. Effect of preparationconditions on the size, morphology, drug loading, and release profiles of micropheres wasinvestigated. Based on in vitro release experimental findings, a diffusion/dissolution model waspresented for quantitative description of the resulting release behaviors and drug release kineticsfrom PLA microspheres analyzed. The mathematical models were used to predict the effect ofmicrostructure on the resulting drug release. It provided an approach to determine the suitablestructure parameters for microspheres to achieve desired drug release behaviors.
基金
SupportsbytheNationalScienceFundforDistinguishedYoungScholars(No.20225620)theNationalNaturalScienceFoundationofChina(No.20376025)theOutstandingYoungProfessorAwardfromGuangdongProvinceBureauofEducation.
关键词
聚乳酸微球
结构性能关系
释放性能
模型
药物释放
溶剂蒸发
microspheres
drug delivery
nifedipine
controlled release
solventevaporation
structure-property relationships
model
