贵州汞污染地区大米神经毒性基因水平研究

Study the neurotoxicity in gene level of rice from mercury contaminated areas in Guizhou.

为从分子基因水平探讨汞污染地区大米的神经毒性,用贵州 2 个汞污染区(万山汞矿和清镇化工厂)产的大米喂养大鼠,分别于20d 和30d 后,用 RT-PCR 方法检测脑中即刻早期基因 c-fos mRNA 表达变化,并以非污染区作对照.结果表明,汞污染大米能够极显著诱导大鼠脑c-fos mRNA 表达,并且该表达是持续的.应用 c-fos mRNA 表达变化早期预报汞神经毒性是有可能的.

In order to probe into the neurotoxicity in gene level of rice from typical mercury contaminated areas in Guizhou, the expression change of c-fos mRNA in rat brain using rice produced in Wanshan and Qingzhen of Guizhou to feed rat after 20 days and 30 days was observed with reverse transcription polymerase chain reaction (RT-PCR) methods, and compared with the non-polluted control area. The mercury polluted rice induced significantly the expression of c-fos mRNA in rat brain, and the expression was continued. It could be inferred that applying the expression change of c-fos mRNA it could be possible to forecast the early neurotoxicity.