摘要
AIM:To develop the general route for the synthesis of gefitinib.METHOD: 2-Amino-4,5-dimethoxybenzoic acid was cyclized,monodemethylated,acetylated,ammoniated and chlorinated to obtain the target compound.RESULT:The structure was confirmed by elemental analysis, IR and 1H NMR.CONCLUSION:Synthetic route and methods is feasible for the preparation of gefitinib.
AIM:To develop the general route for the synthesis of gefitinib.METHOD: 2-Amino-4,5-dimethoxybenzoic acid was cyclized,monodemethylated,acetylated,ammoniated and chlorinated to obtain the target compound.RESULT:The structure was confirmed by elemental analysis, IR and 1H NMR.CONCLUSION:Synthetic route and methods is feasible for the preparation of gefitinib.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2005年第1期92-94,共3页
Journal of China Pharmaceutical University
