胃癌组织中层连接蛋白受体的表达及其意义

Expression and significance of laminin receptor in gastric cancer

目的 :探讨层连接蛋白受体 (LN R)在胃癌中的表达 ,及与胃癌侵袭转移和预后的关系。方法 :对我院 1994年 5月 1日～ 1998年 9月 3 0日经病理诊断明确、随访资料完整的 65例胃癌组织标本、3 1例癌旁组织 ,采用免疫组化SP法检测LN R的表达情况 ,分析其与胃癌临床特征、预后间的关系。结果 :胃癌中LN R阳性表达率为 3 8 5 % ( 2 5 / 65 ) ,阳性细胞表达产物主要见于细胞膜和细胞质 ,癌旁组织阳性表达率为 9 7% ( 3 / 3 1) ,两者间相比差异有统计学意义 ,P =0 0 0 4。胃癌组织中LN R阳性表达与患者性别、年龄、病变部位、病理分化程度无关 ;与肿瘤大小、大体形态、浸润深度、淋巴结转移、临床分期密切相关 ,P值分别为 0 0 0 6、0 0 0 8、0 0 0 1、0 0 0 9及 0 0 0 1;阳性表达者根治术后复发转移率及死亡率均高于阴性者 ,P值分别为0 0 46及 0 0 0 79。结论 :1)胃癌组织中存在着LN R蛋白高表达现象。 2 )LN R与胃癌侵袭转移的发生密切相关 ,肿块越大、浸润深度越深、临床分期越晚 ,LN R蛋白表达水平越高 ;LN R可作为判断胃癌细胞侵袭转移力的指标 。

OBJECTIVE: To investigate the expression of laminin receptor (LN-R) in the patients with gastric cancer, and their correlation with invasion, metastasis and prognosis of gastric carcinoma. METHODS:Sixty-five gastric cancer and 31 adjacent noncancerous specimens, which had histological diagnosis and complete follow-up data in our hospital from 1994-1998, were detected by the immunohistochemical assay for the expression of LN-R.RESULTS:The positive rate of LN-R in the gastric cancer tissues was significantly higher than that in the adjacent noncancerous tissues (38.5% vs 9.7%;P<0.05), its positive expression was at cytoplasm and membranes and associated with tumor size, morphological type of cancer, invasiveness depth, lymph node metastasis and TNM stage, but not related with sex, age, location and histological differentiation of cancer.The positive patients had higher recurrence, metastasis rate and mortality than negative ones after radical resection (P=0.046 and 0.007 9).CONCLUSIONS:There exist higher expression of LN-R in gastric cancer. The positive LN-R patients have more recurrence,metastasis than negative ones, therefore it may be a good marker for predicting invasion and metastasis of gastric cancer,and the expression of LN-R has a close relationship with prognosis of gastric cancer.