原发性视网膜色素变性免疫发病机理的探讨

Study on Immunologic Pathogenesis of Primitive Pigment Degeneration of Retina

采用单克隆抗体等技术对60例RP患者T细胞亚群、免疫球蛋白、补体及循环免疫复合物等指标作了检测,结果表明:RP患者T_1、T_4、T_8、C_3、C_4降低,T_4/T_8、IgM、GIG增高,与对照组比较差异有显著性意义,其中C_3下降与CIC增高,C_4下降与CIC增高显著相关。据此对RP的免疫发病机理作了推测,提出了自身免疫反应致病的假说。

Using monoclinal antibody technique, Tlymhhocyte cell subgroups, immunoglobins, complements, and circulating immune complexes (ClC) were measured in 60 patients with primitive pigment degeneration of retina (RP). The results indicated that T_1, T_4, T_8, C_3 and C_4 of the patients were lower than those of the control; T_4/T_8, IgM and CIC of the patients were more than those of controls. The differences between the patients and the controls were remarkably significant. Among them, the reduction of C_3 was related with increasing of CIC and the reduction of C_4 was related with increasing of CIC. For the above result, we investigated the assumption that auto-immune response leads to RP.