摘要
在兔眼玻璃体内移植５０００００个同种异体皮肤纤维细胞后，玻璃体内一次性注射γ干扰素显著降低牵引性视网膜脱离的发生率。第一周，对照组为４０％（２０眼中８眼），治疗组仅１０％（２０眼中２眼）（Ｐ＜０．０５）。第四周，对照且１００％（２０眼中２０眼），治疗组降为６０％（２０眼中１２眼）（Ｐ＜０．０１）。实验表明γ干扰素对防治增殖性玻璃体视网膜病变有效，玻璃体内注射γ干扰素１０＾４单位对眼部无毒性作用。
A single intravitreal injection of γ interferon was effective in the treatment of experimental rabbit models of proliferative vitreoretinopathy. When given with an intravitrael autotransplantation of 50000 heterologous fibroblasts, γ interferon decreased the rate of tractional retinal detachment from 40% in controls (eight of 20 eyes) to 10% in treated animals (two of 20 eyes) at one week (P<0.05), and from 100% in contrels Twenty of 20 eyes to 60% in treated animals(twelve of 20 eyes) at four weeks (P<0.01). The experimentshowed that γ interferon 10~4 unit intra(?)treal injection had no toxic effect.
出处
《眼科研究》
CSCD
1993年第4期259-261,共3页
Chinese Ophthalmic Research
关键词
成纤维细胞
干扰素
视网膜病变
fibroblasts, injection, interferon, detachment, proliferative vitreoretinopathy.
