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CD44v6、nm23-H1在大肠癌中的表达与预后的关系

Expression of CD44v6 and nm23-H1 protein and in colorectal carcinoma and correlation with it' s prognosis
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摘要 [目的]探讨CD44v6及nm23-H1蛋白的表达与大肠癌的临床病理意义以及其对大肠癌预后判断的价值.[方法]应用免疫组化技术对52例大肠癌进行上述指标的表达及对比研究.[结果]大肠癌中CD44v6及nm23-H1的阳性表达率分别为65.4％及36.5％.CD44v6与分化程度有关,而nm23-Hl与分化程度无关.二者与肿瘤临床Duke's分期及淋巴结转移密切相关(P<0.05).[结论]CD44v6及nm23-H1的联合检测对判断大肠癌预后有参考价值. [Objective]To evaluate the relationship between the expression of CD44v6 amd nm23-H1 and the biologic behaivious of colorectal tumor and their potential usage in prognosis of colorectal cancer. [Methods] With immunohistochemical assay, 52coloretal carcinomas were studied. [Results] The postive rates of CD44v6 and nm23-H1 expression were 65. 4% and 36. 5% respectively. CD44v6 is related to the histological patterns, but nm23-H1 is not related to the histological patterns. The two genes are all related to the Duke's stage and lymph node meastasis and postoperative (P < 0.05). [ Conclusion] :The expression of CD44v6 and nm23-Hl proteins maybe useful in considering the prognosis of colorectal cancer.
作者 陈越
机构地区 大连大学附属医院
出处 《大连大学学报》 2004年第6期68-70,共3页 Journal of Dalian University
关键词 大肠肿瘤 CD44V6 NM23-H1 免疫组化化学 colorectalcarcinoma CD44v6 nm23-H1 immunohistwhemistry
分类号 R735.34 [医药卫生—肿瘤]
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参考文献5

  • 1[1]CORNELIA T, MARTIN H, PETER H, et al. Splicing choice from ten variant exons establishes CD44 variability[J]. Nucleic Acids Research, 1993,21 (5): 1225-1229.
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二级参考文献6

  • 1刘宝瑞,张学庸,丁杰.nm23蛋白在转移性胃癌中的表达[J].中华病理学杂志,1996,25(5):307-308. 被引量：10
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大连大学学报
2004年 第6期

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