去甲斑蝥酸钠白蛋白微球的研究

STUDY ON SODIUM NORCANTHARIDATE ALBUMIN MICROSPHERES

选择去甲斑蝥酸钠为模型药物,对含药白蛋白微球的制备、载药性能、形态、表面状态、大小及分布、体外释药、冷冻干燥、^(60)Co辐照灭菌和稳定性等进行了研究。结果表明,去甲斑蝥酸钠微球的平均大小为0.43±0.12μm,药物含量为20.34～26.75μg/ml,包入率21.9～26.4%,体外释药符合Higuchi方程,冷冻干燥和^(60)Co辐照对微球无影响且能达到无菌要求,放置3个月后微球的稳定性良好。

In this paper sodium norcantharidate (Na_2NC) was chosen as model drug and sodium norcantharidate albumin microspheres(Na_2NC AM) was prepared by an optimal procedure. The embedding nature, appearance, morphology, size and size distribution, release characteristics in mtro, freeze—drying, ^(60)Co radiosterilization and stability of Na_2NC AM were tested. The results showed that the mean size was 0.43±0.12 μm, embedding concentration was 20.34～26. 75 μg/mg, embedding ratio was 21.9～26.4%, release characteristics in vitro was in accord with Higuchi equation. Freeze—drying and ^(60)Co radiosterilization showed no influence on Na_2NC AM. The stability of Na_2NC AM was good after 3 months storage.