葡萄胎恶性趋势探讨

HETEROZYGOUS 46,XX COMPLETE MOLES HAVE A SUBSTANTIAL INCREASED RISK FOR MALIGNANCY

对97例葡萄胎进行了细胞遗传学分析、病理学检查和临床分析。97例中15例属部分性葡萄胎,核型为三倍体,82例属完全性葡萄胎,核型为二倍体。82例中62例是纯合子,核型为46,XX,20例是杂合子,其中11例核型是46,XX,9例是46,XY。完全性葡萄胎中18例是恶性病例,恶变率为22%(18/82),其中8例纯合子,恶变率12.9%(8/62),10例杂合子,恶变率50%(10/20)。均为46,XX。因此,杂合子46,XX完全性葡萄胎恶变率为90.9%(10/11)。而9例46,XY和15例三倍体中无一例发生恶变。可见完全性葡萄胎比部分性者恶变率高,杂合子完全性葡萄胎比纯合子者恶变率高。

The results of cytogenetic,pathologic and clinic analysis for97 hydatidiform moles had been investigated from March 1985 to June1988.There were 15 triploid(partial moles pathologically)and 82 diploid(complete moles pathologically)in which 62 homozygous 46,XX,11heterozygous 46,XX and 9 cases of 46,XY moles were identified.All of18 malignant cases came from complete moles,the malignant rate of whichwas 22% and 12.9%,50% 90.9% in homozygous XX group,heterozygousmoles,and heterozygous XX moles respectively.No malignancy occurredin the 46,XY and triploid group.Hence the malignant rate was higherin complete moles than that in partial moles,and the heterozygous XXmoles have more malignant potential than the homozygous type(P<0.01).