醋酸棉酚对大鼠输卵管平滑肌收缩活动的影响

EFFECTS OF GOSSYPOL ACETIC ACID ON THE MOTILITY OF RAT OVIDUCT SMOOTH MUSCLE

观察了醋酸棉酚水溶性制剂对离体大鼠输卵管平滑肌收缩活动的影响并对其作用机制作了初步探讨。结果表明,醋酸棉酚可提高大鼠输卵管平滑肌收缩张力,但并非为激动α兴奋性肾上腺素能受体,而与促输卵管组织前列腺素(PGs)的生物合成、释放并与促Ca^(2+)内流机制有关。棉酚的这种药理作用还与性周期有密切关系,对动情期输卵管的作用明显高于间情期。结果还表明,前列腺索E_1(PGE_1)和前列腺素E_2(PGE_2)均可提高大鼠输卵管平滑肌收缩活性,以PGE_1的作用较强且较持久,此作用可为醋酸棉酚所明显增强。

The effects of gossypol acetic acid (GAA) on the contractile activity of rat oviduct smooth muscle were studied in vitro with an attempt to clarify its mechanism of action. The result showed that GAA apparently increased the contractile tension of oviduct smooth muscle. This effect was not the result of excitation of the α-adrenergic receptor, but due to promotion of PGs biosynthesis and release. It might also be related to an increase in Ca^(2+) influx in the tissue. The pharmacological effect of GAA was also shown to be relevant to sexual cycle. The action of increasing contractile tension by GAA on the estrus duct was much larger than that on the diestrus duct. In addition, the results indicate that PGE_1 and PGE_2 increased the contractile activity of oviduct, the action of PGE_1 was more potent than that of PGE_2, and this effect was found to be increased significantly by GAA.