摘要
以小鼠为实验对象,观察了拟胆碱药物对赛拉嗪镇静效应的影响,催醒宁(0.25～1.0mg·kg^(-1)),溴代胆碱(100～300 mg·kg^(-1))以及槟榔碱(1.0～5.0 mg·kg^(-1)),均可显著拮抗赛拉嗪的镇静效应。催醒宁(0.25 mg·kg^(-1)和密胆碱(3μg icv)分别使赛拉嗪镇静效应量效曲线显著右移和左移。结果提示,赛拉嗪对中枢胆碱能系统功能产生抑制作用,在拮抗赛拉嗪镇静,以及赛拉嗪复合麻醉的催醒方面,催醒宁可能有潜在的应用价值。
Xylazine induced sedation in mice was observed as a kind of inhibition of exploratory activity. The reversible cholinesterase inhibitor cui xing ning (0. 25～1.0 mg. kg^(-1)), the preeusor of acetylcholine, choline bromide (100～300 mg. kg^(-1) ), and the M-receptor agonist arecoline ( 1.0～5.0 mg. kg^(-1) ) were shown to significantly antagonize xylazine (5. 0 mg. kg^(-1) ) induced sedation. While cui xing ning (0. 25 mg. kg^(-1)) shifted the dose-response curve of xylazine induced sedation to the right, hemicholinum-3 (3 μg icv ), which inhibits the synthesis of acetylcholine, shifted the dose-response curve to the left. These results suggest that the xylazine induced sedation may be partly due to a reduced central cholinergic function. Cui xing ning may have some value in the treatment of xylazine overdose and antagonize the anesthesia induced by anesthetics combined with xyiazine.
出处
《药学学报》
CAS
CSCD
北大核心
1993年第3期172-176,共5页
Acta Pharmaceutica Sinica
关键词
寒拉嗪
镇静
胆碱
Xylazine
Sedation
Cui xing ning
Choline bromide: Arecoline
Hemicholinum-3
