川续断中皂甙Ⅺ,Ⅻ和ⅩⅢ的结构研究

STRUCTURE DETERMINATION OF SAPONIN Ⅺ, Ⅻ AND ⅩⅢ FROM DIPSACUS ASPER WALL

从川续断(Dipsacus asper Wall.)根的醇提物中得到三个微量新三萜皂甙(Ⅺ～ⅫⅠ),根据光谱分析和化学反应,其结构分别鉴定为3-O-[β-D-吡喃葡萄糖(1→4)][α-L-吡喃鼠李糖(1→3)]-β-D-吡喃葡萄糖(1→3)-α-L-吡喃鼠李糖(1→2)-α-L-吡喃阿拉伯糖-常春藤皂甙元(Ⅺ)、Ⅺ的28-O-β-D-吡喃葡萄糖(1→6)-β-D-吡喃葡萄糖酯甙( Ⅻ)和3-O-[β-D-吡喃木糖(1→4)-B-O-吡喃葡萄糖(1→4)][α-L-吡喃鼠李糖(1→3)]-B-D-吡喃葡萄糖(1→3)-α-L-吡喃鼠李糖(1→2)-α-L-吡喃阿拉伯糖-齐墩果酸-28-O-β-吡喃葡萄糖(1→6)-β-D-吡喃葡萄糖酯甙(ⅫⅠ)。

Three new triterpenoid glycosides (Ⅺ, Ⅻ and ⅩⅢ) were isolated from the ethanol extract of the roots of Dipsacus asper Wall. Their structures were deduced as 3-O-[β-D-glucopyranosyl (1→4)] [α-L-rhamnopyranosyl (1→3)]-β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→2)-α-arabinopyranosyl-hederagenin (Ⅺ), 28-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl ester of Ⅺ (Ⅻ) and 3-O-[β-D-xylopyranosyl(1→4)-β-D-glucopyranosyl(1→4)][α-L-rhamnopyranosyl (1→3)]-β-D-glucopyranosyl (1→3)-α-L-rhamnopyranosyl(1→2)-α-arabinopyranosyl-oleanolic acid 28-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl ester (ⅩⅢ), respectively, based on spectral and chemical analysis.