华钩藤中新的氧化吲哚生物碱甙

NEW OXINDOLE ALKALOID GLYCOSIDES FROM UNCARIA SINENSIS

自中药华钩藤(Uncaria sinensis[Oliv]Havil)叶子的乙醇提取物中分得2个16-位羧基氧化吲哚生物碱和2个它们的葡萄糖酯甙。经化学和光谱方法(UV,IR,FAB-MS,~1H-NMR,^(13)C-NMR,CD)分别鉴定了它们结构,并命名为帽柱木菲酸(mitraphyllic acid,Ⅰ),异帽柱木菲酸(isomitraphyllic acid,Ⅱ),帽柱木菲酸[16-1]-β-D-吡喃葡萄糖酯甙(mitraphyllic acid[16-1]-β-D-glucopyranosyl ester,Ⅳ)和异帽柱木菲酸(16-1)-β-D-吡喃葡萄糖酯甙(isomitraphyllic acid[16-1]-β-D-glucopyranosyl ester,Ⅲ)。除化合物Ⅰ外,其余均为首次从天然得到的新化合物。

Two 16-carboxy derivatives of pentacyclic oxindole alkaloids and its glucopyra nosyl esters have been isolated from the ethanolic extract of the leaves of Uncaria siuensis (Olive.) Havil. These structures were deduced on the basis of spectroscopic evidences and chemical correlations, and named mitraphyllic acid (Ⅰ), isomitraphyllic acid (Ⅱ), isomitraphyllic acid (16-1)-β-D-glucopyranosyl ester (Ⅲ) and mitraphyllic acid (16-1)-β-D-glucopyranosyl ester (Ⅳ).