rhG-CSF治疗30例肺癌化疗所致的白细胞减少症疗效观察

Therapeutic Effect of rhG-CSF on Leukopenia Induced by Chemotherapy for Patients with Lung Cancer

目的 :观察基因重组人粒细胞集落刺激因子 (rhG CSF ,特尔津 )对肺癌化疗所致的白细胞减少症的疗效。方法 :用rhG CSF治疗 3 0例肺癌化疗所致的白细胞减少患者 ,随机与用其他口服升白细胞药物治疗 3 0例肺癌化疗所致的白细胞减少患者 ,进行对比观察。结果 :rhG CSF和其他口服升白细胞药均能使化疗后白细胞减少症患者的白细胞数恢复至正常范围 ( 4× 10 9/L) ,但rhG -CSF组白细胞数回升至正常的时间比其他口服升白细胞药物组明显缩短 (P <0 0 0 2 ) ,且其继发性感染发生率明显降低 (P =0 0 2 99)。结论 :rhG CSF可有效治疗化疗所致的白细胞减少症 ,并能减少继发性感染机会 。

Objective: To study the effect of recombinated human granulocyte Colony-stimulating factor(rhG-CSF,Topneuter) on leukopenia caused by chemotherapy.Methods:Thirty cases with leukopenia caused by chemotherapy for patients with lung cancer were treated with rhG-CSF,and compared with 30 cases treated with oral leukopenic medicines.Results:All patients with leukopenia recovered to nomal after treatment either with rhG-CSF or with oral leukopenic medicines,the period of leukopenia recovered to normal was shorter in the group with rhG-CSF treatment than that in the leukopenic drugs group(P<0 002) A significant decrease was also shown for rhG-CSF group in the incidence of infection(P=0 03).Conclusion:Topeneuter was effective for the treatment of leukopenia after chemotherapy,and it may decrease infection incidence during chemotherapy.