摘要
作者用宽叶缬草挥发油(Val-I)治疗冠心病(CHD)心绞痛82例(其中心肌缺血50例),总有效率分别达87.80%,88%,比对照组复方丹参注射液(SMCo)治疗心绞痛34例(其中心肌缺血21例).总有效率41.18/,37.50%,差异非常显著(P<0.001;P<0.01)。本文还探讨了Val-I的作用机理和临床应用特点,提示宽叶缬草是一种治疗CHD的新型有效药物。
Valeriana officinalis L. var latifolia Miq., which is variety of valeriana officinalis L, has the properties to relieve smooth muscle spasm and powerfully to expand coronary artery, as demonstrated by animal experiments; no report on its application to treating coronary heart disease (CHD)has been found as yet with Val-I, our preparation of a volatile oil fractionated from its root ,we have treated 82 CHD patients with angina pectoris, among whom ST-T ischemic changes appeared on conventional ECG in 50 cases defore treatment. Its total effective rate for the simple angina (without detectable ischemic findings) was 87.80%; the angina with ischemic findings,88.00% , For comparisons, another 34 patients with the same conditions,24 cases among them belonging to the angina with ischemic findings, were treated with SMCo, a composite injection of Salvia Miltiorrhiza(Shanghai First Pharmaceutieal Factory); the total effective rates for the simple simple angina and for the angina with ischemic findings were 41. 18% and 37. 50% respectively. Statistically, the efficiency differences between Val-I and SMCo were both highly significant(P<0. 001,P<0. 01) either in the simple angina or in the angina with ischemic findings when tested separately. The results showed Valeriana officinalis L, var latifolia Miq. to be quite effective on the angina pectoris due to CHD with or without myocardial ischemic findings, and to be superior to SMCo whether in the remission of symptoms, decreasing the attack frequency and shortening the attack duration of the angina, or in restoring the blood supply to the ischemic myocardium. In addition , it was discovered that Valeriana officinalis L.var latifolia Miq. could lower plasma lipids as well. And , toxic actions causing function impairments of liver, kidney , hemopoietic tissue (leukopenia) etc,have not been detected, The mechanisms concerning its therapeutic effects mentioned above are also discussed in detail.
关键词
宽叶缬草
冠心病
临床研究
中医药疗法
Valeriana officinalis L.var latifolia Miq.Val-I coronary heart disease angina pectoris myocardial ischemia plasma lipids