链霉素致耳聋易感家系分析

ANALYSIS OF FAMILIAL STREPTOMYCIN INDUCED DEAFNESS

对宁夏某县某大家系健在的１０１人进行了回顾性调查，其中应用过链霉素者２６人，２１人于用药后１月～６个月发生耳聋。２６人中属男性下传的子代４人均为阴性；属女性下传的子代２２人，其中２１人阳性（耳聋）。经对大谱系及其中的Ⅱ１（Ａ）小谱系分析，作者认为，此种迟发性链霉素致耳聋（ＳＩＤ）家系是易感因子通过母系遗传。

A retrospective survey was made on 101 living members of a largepedigree susceptible to streptomycin-induced deafness(SID)in a coun-ty of Ningxia, China in 1990.Among them 26 had streptomycin adminis-tration history in 60's, 70's or 80's respectively and 21 of which deve-loped ototoxic deafness within 1─6 months after receiving streptomycintreatment.The distribution of the 21 patients in each year suggested that the deafness in the family was related with the streptomycin adminis-tration.Among the 26,four of the filial generations of paternity hadnormal audition,while 21 of the 22 of the filial generations of mater-nity had abnormal audition(deafness),but one normal.There is asignificant difference between the two groups(P<0.01).It can be con-cluded that maternal genotype s predominant in the inheritance of SID.The filial generations of the maternity are subject to SID once strepto-mycin is administered and should avoid receiving this drug.