BUdR对人外周血淋巴细胞遗传学效应几项指标的研究

Genetic Effect of 5-Bromo-2-Deoxyuridine on Peripheral Human Lymphocytes

为了研究ＢＵｄＲ的遗传学效应，本研究采用染色体畸变分析、微核测定和细胞分裂指数３项指标，对４８例人外周血淋巴细胞进行观察。结果表明：利用渗入ＢＵｄＲ的培养方法来研究细胞动力学和微核发生率，以监测致癌物和致突变物，特别呈弱致癌物和弱致突变物，是不恰当的。

In our research on the genetic effect of 5-bromo-2-deoxyuridine(BUdR), we ob-served 48 cases of peripheral human lymphocytes through analysis of chromosome distortion,deten1lination of micronucleus and index of cell cleavage, The result showed that it is notappriate to monitor carcinogen and mutage, especially weak carcionogen and weakmutagen,in the research of cytodynamics and micronucleonic occurrence rate by means ofBUdK-adding culture。