赤栀黄煎剂预防实验性肝硬变发生的形态学研究

MORPHOLOGICAL STUDY ON THE ACTION OF PGRDECOCTION IN PREVENTING THE DEVELOPMENT OF EXPERIMENTA LIVER CIRRHOSIS

实验大白鼠分三组：肝硬化组给以四氯化碳（ＣＣｌ４）等复合因素；给药组除ＣＣｌ４等复合因素外，给以赤栀黄煎剂灌胃４１天；正常组给予一般饮食及饮用水。结果给药组与肝硬化组相比，肝硬化形成率明显降低，肝小叶损伤区域明显缩小，肝细胞中脂滴减少，细胞核增大，ＲＮＡ及核仁增多，糖原恢复，ＳＤＨ、Ｇ－６－Ｐａｓｅ活性增强。表明赤栀黄合剂能减轻ＣＣｌ４等复合因素引起的肝硬变，并对其机理进行了讨论。

This paper presents the histology and histochemical study of the liv-er cirrhosis of rats treated by PGR decoction (Paeonia rubra, Garde-nia jasminoides, Rheum palmatum).Forty-eight wistar rats were divid-ed into three groups.The liver cirrhosis group (14) was medicatedwith CCl4 and other compound factors(such as high grease diet andalcohol drink),the treated group(20) was given PGR decoction throughgastric intubation for forty-one days besides CCl4 and other compoundfactors, while the control group(14)was administered with normal foodsand water only.From the experimental result of the treated group displ-ayed the rate of liver cirrhosis was obviously decreased as comparedwith the liver cirrhosis group(P<0.01).In hepatic lobule the ne-crotic area and the liver cellular fat droplets decreased.And RNA,gly-cogen, nucleolus increased,and SDH,G-6-Pase activity increased aswell. According to this observation, it is suggested that the PGR decoc-tion available can decrease liver cirrhosis caused by CCl4 and other co-mpound factors.Its machamism may be that the PGR decoction can pre-vent the damage of endoplasmic reticulum, promote protein synth esisand detoxiation and decrease the damage of mitochondria.And the heapof the liver cellular fat droplets decrease.Then the liver cellular nec-rosis and inflammation reaction decrease too. Therefore the formationof fibrolast and collagenous fiber is decreased, so the liver cirrhosiscan be prevented.