摘要
内毒素1mg/kgipd4豚鼠气道His引喘潜伏期明显缩短,His反应性增强,其PD2值增大,β受体功能降低,ISO的PD2值下降,血浆中cAMP水平降低,甘草酸单铵(GL)50mg/kgip×4d明显抑制ip内毒素后His反应性增高及β受体反应性降低,并显著提高血浆cAMP水平。提示GL对细菌感染诱发的支气管高反应性有预防作用,其作用机制与GL对β-cAMP系统向上调节有关。
days after endotoxin 1mg/kg intraperitoneal injection,the latent peroids of guinea pig inhaled histamine and PD2value of ISO and cAMP levels of plasma were decrease. meanwhile PD2 value of histamine decreased significantly.Ammonium Glycyrrhizanate50mg/kg ip×4inhibited the effect of endotoxin and incteased cAMP levels of plasma.The results indicated GL could prevent bscterial infection induced bronchial hyperreactivity. The mechanism may be inretation to that GL could be up regulation of β-cAMP system.
出处
《中药药理与临床》
CAS
CSCD
1994年第1期17-18,共2页
Pharmacology and Clinics of Chinese Materia Medica