济南假单胞菌细胞壁组分(PJ-CW)对荷瘤小鼠免疫功能调节的研究

Studies on the Regulation of Immune Function of PJ-CW in Tumor-bearing Mice

PJ-CW是新抗癌剂济南假单胞菌苗(PJV)的第二代制剂。本文总结了PJ-CW对荷瘤小鼠免疫功能调节的观察。结果显示,PJ-CW不仅能促进和调节荷瘤小鼠腹腔Mφ吞噬功能、CTL杀伤活性、NK活性和外周血ANAE^+细胞数量以及人胎脾LAK细胞的杀伤活性,还能促进小鼠腹腔渗出细胞和淋巴细胞环核苷酸的含量,为PJ-CW的抗癌作用提供了实验依据。

PJ- CW is the second preparation of PJV. In this article a series ot experimental studies of immune function both in vitro and in vivo were carried out. The results suggested that PJ-CW can not only enhance and modulate the phagocytic function of intraperitoneal Mφ in mice, the anti - tumor effect of CTL, the activity of NK cell, the amount of ANAE+ cell as well as LAK killing activity of human fetal spleen, but also improve and modulate the content of cyclic nucleotide both in mouse abdominal exudative cell and spleen cell. Thus it provides the experimental basis for anti-tumor effect on PJ-CW.