妊娠早期巨细胞病毒活动性感染患者可溶性白细胞介素-2受体水平与病毒宫内感染的关系被引量：1

Relationship between soluble IL-2R level and intrauterine infection of early pregnant women with active cytomegalovirus infection

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摘要目的: 探讨巨细胞病毒活动性感染的早期妊娠妇女外周血可溶性白细胞介素 -2受体 (SolubleInterleukin-2Receptor, sIL-2R) 水平与巨细胞病毒 (cytomegalovirus, CMV) 宫内感染的相关性。方法: 应用酶联免疫吸附试验和逆转录聚合酶链反应方法筛查出巨细胞病毒活动性感染孕妇 134例, 测定其外周血中sIL-2R水平, 并通过超声影像动态观察其子代生长发育情况直至终止妊娠, 流产、引产或分娩后检测子代标本确定有无宫内感染。结果: 134例研究对象中, 足月分娩者 77例,妊娠结局不良者 10例, 获得子代标本者 64例, 其中 21例CMVDNA阳性, 其母体外周血sIL-2R平均水平 258 41±15 44U/ml, 43例无宫内传播者母体外周血sIL-2R平均水平 188 41±21 35U/ml, 两者差异具有统计学意义 (t=2 52, p=0 02)。10例妊娠结局不良者孕妇外周血sIL-2R平均水平 (223 66±25 15U/ml) 高于 77例足月分娩孕妇 (166 67±18 17U/ml)。结论: 巨细胞病毒活动性感染的早期妊娠妇女外周血中sIL-2R水平与病毒宫内传播有一定相关性, 出现流产、死胎等异常妊娠结局者外周血sIL-2R水平具有升高趋势。 Objective:To explore the relationship between peripheral serum soluble interleukin-2 receptor (sIL-2R) levels and cytomegalovirus (CMV) intrauterine infection of early pregnant women with active CMV infection Methods:134 pregnant women with active CMV infection were screened with ELISA and PT-PCR to determine peripheral blood sIL-2R levels And the fetus growth was dynamically observed with ultrasonography till pregnancy termination The fetus samples were detected to ensure intrauterine infection or not after abortion, induced labor or delivery Results:Of 134 objects, there was 77 cases of full-term delivery, 10 ones with poor pregnant outcome Of 64 examples, there was 21 ones with positive CMV DNA and their matrix peripheral blood sIL-2R levels were averagely 258 41±15 44 U/ml, 43 ones without intrauterine transmission and their matrix peripheral blood sIL-2R levels were averagely 188 41±21 35 U/ml, there was significant difference between two groups ( t =2 52, P =0 02) The average peripheral blood sIL-2R levels (223 66±25 15 U/ml) of 10 pregnant women with poor outcome were higher than that of 77 pregnant women with full-term delivery (166 67±18 17 U/ml) Conclusion:The peripheral blood sIL-2R levels in early pregnant women with active CMV infection should be related to intrauterine infection The peripheral blood sIL-2R level in pregnant women with abnormal pregnant outcome, including abortion, dead fetus et al, has increasing trend

作者王慧燕陈素华

机构地区湖北省武汉市第十二医院妇产科华中科技大学附属同济医院妇产科

出处《中国妇幼保健》 CAS 北大核心 2005年第4期433-435,共3页 Maternal and Child Health Care of China

基金国家自然科学基金资助项目 (批准号 39970769)

关键词早期妊娠巨细胞病毒感染可溶性白细胞介素-2受体 Early pregnant Cytomegalovirus (CMV) Infection Soluble interleukin-2 receptor (sIL-2R)

分类号 R714.2 [医药卫生—妇产科学]

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