小剂量尿激酶对不稳定型心绞痛患者内皮素及纤溶酶原活性的影响

The effects of low dose of urokinase on endothelin and activities of endothelial tissue plasminogen in patients with unstable angina pectoris

目的:评价小剂量尿激酶对不稳定型心绞痛患者内皮源性血管活性物质内皮素 1、组织型纤溶酶原活性的影响,以探讨小剂量尿激酶治疗心绞痛的机制。方法:选择80例心电图负荷试验阳性、动态心电图出现缺血性改变的不稳定型心绞痛患者,静脉应用小剂量尿激酶3 d,于治疗前后分别测定内皮素 1、组织型纤溶酶原激活物及其抑制剂的变化。结果:与治疗前相比较,组织型纤溶酶原激活物升高,内皮素 1 及组织型纤溶酶原激活物抑制剂下降,其变化均具有显著性。结论:小剂量尿激酶可明显调节不稳定型心绞痛患者的内皮源性血管活性物质如内皮素 1、组织型纤溶酶原激活物及其抑制剂的活性。

Objective:To evaluate the effects of low dose of urokinase on endothelin and activities of endothelial tissue plasminogen in patients with unstable angina pectoris.Method:Eighty patients of unstable angina pectoris were studied. Their stress tests were abnormal and there were ischemic changes in Holter. Urokinase was used for 3 days through vein injections.Before and after urokinase treatments, endothelin-1, plasma tissue plasminogen activator and inhibitor-1 were determined. Result:Compared with pretreatments, after treatments, the activities of tissue plasminogen activator increased. Endothelin-1 and the inhibitor-1 decreased. The changes are significant. Conclusion:Low dose of urokinase can regulate the endothelial vasoactive substances in patients with unstable angina pectoris .The common substances include endothelin-1、plasma tissue plasminogen activator and inhibitor-1.So unstable angina pectoris can be treated by urokinase effectively.