血栓通对急性脑梗死患者凝血及血液流变性的影响

Treating Acute Cerebral Infarction with Xueshuantong and Its Effect on Dynamic Data of Coagulation, Fibrinolytic System and Hemorheology

目的观察血栓通注射液治疗急性脑梗死的疗效及其对患者纤溶、凝血及血液流变性的影响。方法选择急性脑梗死患者60例,随机分为两组,对照组30例予开搏通及丹参注射液等常规治疗。治疗组30例在上述治疗的同时,加用血栓通针剂静脉滴注。观察两组治疗前后神经功能缺损评分(改良爱丁堡+斯堪的纳维亚评分)、血液流变性、D-二聚体、凝血酶原时间、部分凝血活酶时间、纤维蛋白原等变化。结果治疗组疗效明显优于对照组(P<0.05);纤维蛋白原水平下降(P<0.05),D-二聚体升高(P<0.05),部分凝血活酶时间、凝血酶时间延长,血浆粘度值、红细胞聚集指数明显下降(P<0.05),无明显不良反应。结论血栓通对脑梗死有较好治疗作用,并优于传统中药制剂。

Objective: To study the curing effect of Xueshuantong on treating acute cerebral infarctionand its effeft on the dynamic data of coagulation, fibrinolytic system and hemod ynamics. Methods: 60 cases of acute cerebral infarction were chosen and randomly distributed to control group and therapy group. The 30 cases in control group were treated regularly with Danshen injecti on et al, and the 30 cases in therapy group were injected by Xueshuantong on the basis of regular treatment. The protherombin time (PT), activeated partial thromboplasmin time (APTT), fibrinogen, D-Dimer, hemodynamics were observed. Results: The curative effect in treatment group was significantly betterthan that in control group(P<0.05). PT, APPT were prolonged. Fg level, plasma viscosity, RBC aggregation index was greatly decreased(P<0.05). D-Dimer lever were significantly increased (P<0.05).Conclusion: Xueshuantong has good effect on treating acute cerebral infarction, which is better thanregular tradtional Chinese medicine decoction.