社会心理干预对复发性抑郁症患者生活质量等因素的影响

Effect of psychosocial intervention on quality of life and other factors in patients with recurrent depression

目的:探讨社会心理干预对复发性抑郁症患者生活质量、复发率、再住院率以及服药依从性的影响。方法:将新乡医学院第二附属医院复发性抑郁症患者121例随机分为社会心理干预联合抗抑郁药物组(实验组,n=60)及单用抗抑郁药物组(对照组,n=61),采取生活质量量表(WHO-QOL-100)评定两组治疗前、后的生活质量情况。于出院后随访6个月、1年、2年分别了解患者服药依从性情况、复发率及再住院率。结果:两组患者的生活质量均有改善,实验组的生活质量总评、心理领域、独立性领域及社会关系领域评分为13.2±2.43,68.4±11.3,53.2±6.9和37.31±6.27,显著好于对照组(生活质量总评分:11.3±2.3,心理领域:63.53±10.23,独立性领域:49.22±6.18,社会关系领域评分:34.44±5.82),差异有显著性意义(t=4.42,2.49,4.98,2.60,P<0.05～0.001);2年后随防实验组的复发率和再住院率为8%和5%,明显低于对照组(33%/30%),差异有显著性意义(χ2=12.39,12.65;P均<0.05);坚持服药的人数实验组50例,对照组36例,差异有显著性意义(χ2=6.72,P<0.05)。结论:社会心理干预不仅有助于复发性抑郁症患者的治疗,而且可改善患者的生活质量,提高治疗依从性和降低复发率。

AIM:To investigate the effects of psychosocial interventions on quality of life(QOL),recurrence rate,rate of readmission and medication compliance in patients with recurrent depression.METHODS:Totally 121 patients with recurrent depression in the Second Affiliated Hospital of Xinxiang Medical College were randomly divided into experimental group(n=60,treated with psychosocial intervention combined with antidepressants) and control group(n=61,treated with single antidepressant).The pre and post treatment QOL of the two groups were assessed with WHO QOL 100.At 6 months,1 and 2 years after discharge,follow ups were conducted to investigate rates of recurrence and readmission,as well as medication compliance.REUSLTS:The QOL of both the two groups was improved.In the experimental group:the total score of QOL,scores of psychology,independence and social relationship were 13.2±2.43,68.4±11.3,53.2±6.9 and 37.31±6.27 points respectively,significantly higher than those in the control group(11.3±2.3,63.53±10.23,49.22±6.18 and 34.44±5.82 points respectively)(t=4.42,2.49,4.98,2.6,P< 0.05 to 0.001).After 2 years,the rates of recurrence and readmission were 8%and 5%respectively in the experimental group,significantly lower than those in the control group(33%and 30%respectively)(χ2=12.39,12.65,both P< 0.05).Numbers of patients persevering in taking antidepressants were 50 in the experimental group and 36 in the control group respectively,so there was significant difference between them(χ2=6.72,P< 0.05).CONCLUSION:Psychosocial intervention can benefit recurrent depression after discharge,improve the QOL of patients,increase medication compliance and decrease the recurrent rate.