抗抑郁治疗对功能性消化不良患者精神心理因素的调节作用

Adjusting effect of antidepressant treatment on the psychological factors in patients with functional dyspepsia

目的:探讨功能性消化不良(functionaldyspepsia,FD)与精神心理因素的关系及抗抑郁治疗对其的疗效。方法:对100名正常人和100例FD患者进行抑郁自评量表(Zung)评分;将伴有抑郁症状的FD患者随机分为实验组19例和对照组20例对照组给予抗消化不良治疗,实验组在此基础上结合抗抑郁治疗。治疗6～8周,两组治疗后再行量表评分。结果:Zung量表评分显示39%的FD患者有抑郁情绪,正常人及FD患者的量表评分(19.25±5.67和53.91±11.35)比较差异有显著性(t=2.759,P<0.01);对照组和实验组消化不良控制总有效率分别是45%,84%,差异有显著性(χ2=6.39,P<0.01)。结论:FD与精神心理因素关系密切,抗抑郁药治疗能有效地改善FD患者的抑郁和消化不良症状。

AIM:To investigate the relation between functional dyspepsia(FD) and psychological factors and the effect of antidepressant treatment on FD. METHODS:Totally 100 normal subjects and 100 FD patients were assessed with Zung depression self rating scale,and then the FD patients with depression were divided into study group(n=19) and control group(n=20).All the patients were given anti dyspepsia treatment,besides those in the study group received antidepressant treatment,the course was 6 to 8 weeks.Patients in both groups were evaluated with the Zung scale after treatment. RESULTS:The scores of Zung scale showed that 39%of the FD patients were complicated with depression,and the scores were significantly different between normal subjects(19.25±5.67) and FD patients(53.91±11.35)(t=2.759,P< 0.01).There was significant difference in the total effective rate of controlling dyspepsia between the control group(45%) and study group(84%)(χ2=6.39,P< 0.01). CONCLUSION:FD is closely correlated with psychological factors,and antidepressant treatment can effectively improve the depressive and dyspeptic symptoms.