女性吸毒者吸毒特点与乙型及丙型肝炎病毒重叠感染的关系(英文)

Relationship between characteristics of drug using in female drug users and double infection of hepatitis B virus and hepatitis C virus

背景:吸毒行为是吸毒者感染乙型肝炎病毒(hepatitisBvirus,HBV)和丙型肝炎病毒(hepatitisCvirus,HCV)感染的主要原因,女性吸毒者吸毒行为有其自身特点,这些特点与HBV,HCV重叠感染有何关系?目的:了解不同吸毒特点与女性吸毒者HBV,HCV重叠感染率的关系。设计:2002-01进行的以女性吸毒者为研究对象的横断面调查。单位:一所市级医院检验科,一所大学的公共卫生学院流行病学教研究室,一所专业戒毒所。对象:整群抽取株洲市白马垅戒毒所320名女性吸毒人员为调查对象。方法:用自编问卷调查吸毒者吸毒特点,用ELISA法测定其血清中乙型肝炎病毒表面抗原(HBsAg)及抗丙型肝炎病毒抗体(抗-HCV)。主要观察指标:吸毒者HBV,HCV重叠感染与注射吸毒、吸毒年限、吸毒时间、戒毒次数之间的关系。结果:320份血清HBsAg和抗-HCV重叠感染率9.37%,全部为注射毒品者,与非注射吸毒者比较,差异有显著性(χ2=6.276,P<0.05);吸毒年限越长,重叠感染率越高,吸毒时间1～5年与5～10年组的重叠感染率(4.5%和10.3%)差异有显著性(χ2=8.344,P<0.05);戒毒次数≤3次与戒毒次数≥4次的重叠感染率差异有显著性(χ2=9.418,P<0.05);吸毒年限、戒毒次数是影响女性吸毒者HBV、HCV重叠感染的主要因素(OR=1.923,1.597;95%CI=0.964～3.838,0.962～2.652)。?

BACKGROUND:Drug use is the most significant risk factor for viral hepatitis B and C infection.Female drug users present different drug-using characteristics from the other sex.And what about the influence of these characteristics on hepatitis B and C virus(HBV and HCV) double infection? OBJECTIVE:To explore the relationship of characteristics of drug using in female drug users on the incidence of HBV and HCV double infection. DESIGN:It is a cross section investigation of female drug users in January 2002. SETTING:A laboratory separtment,an epidemiological department in a university and a drug dependency treatment unit. PARTICIPANTS:A total of 320 female drug users who were in Baimalong drug dependency treatment unit in Zhuzhou city were recruited in this study. METHODS:The drug-using characteristics were investigated through a questionnaire and the surface antigen of HBV(HBsAg)and antibody against HCV(anti-HCV)in serum were checked with ELISA. MAIN OUTCOME MEASURES:Relationship between HBV and HCV infection and injection of drug,injecting career and abstaining history. RESULTS:The incidence of HBV and HCV double infection in the 320 female drug users was 9.37%.All of those with double infection were injection drug users,which was different from non-injection drug users(χ2=6.276,P< 0.05).Longer career of drug-using meant higher possibility of double infection.The incidence of double infection (10.3%) in those of 5-10 years of drug-using career was higher than that (4.5%) of 1-5 years of drug-using career (χ2=8.344,P< 0.05). And that in those experienced more than 4 times of abstaining was also higher than that less than in those experienced 3 times (χ2=9.418,P< 0.05).Long career of drug using and repeated abstention abstaining were factors that leaded to HBV and HCV double infection(OR=1.923,1.597,95%CI=0.964-3.838,0.962-2.652). CONCLUSION:Injection drug use is the predominant factor that causes double infection of HBV and HCV and long career of drug using and rising in the number of times of abstaining also increase the double infection.