山楂等12种中药对黄曲霉毒素B_1诱变效应的抑制

INHIBITION OF 12 CHINESE TRADITIONAL MEDICINAL HERBS ON MUTAGENIC EFFECT INDUCED BY AFLATOXIN B_1

本文报道临床常用12种中药的丙酮提取液对致癌剂AFB_1诱导TA98移码型、TA100碱基置换型突变株回复突变抑制作用实验 实验12个样品有11个对AFB_1的致突变作用显著抑制效果提示这些中药可能对预防肝癌有意义。

Possible antimutagenic activities of 12 preparations of Chinese traditional medicinal herbs on Salmonella typhimurium TA98 and TA100 mutants were tested. Afesatoxin B 1 was used as mutagen . The results showed that 11 of 12 preparations had remarkable inhibitory effect on aflatoxin B 1 induced mutagenic activity for strains TA98 and TA100. This experiment provides a scientific basis to the study of Chinese traditional medicinal herbs resources as preventive substances of carcinogenesis.