Nafion修饰玻碳电极对痕量维拉帕米的测定

DETERMINATION OF TRACE VERAPAMIL ON NAFION-MODIFIED GLASSY CARBON ELECTRODE

盐酸维拉帕米(verapamil VR^+)是一种较重要的钙通道阻滞药,现行标准的分析法为非水滴定法,此外,尚有气相色谱法、高效液相色谱法和电极法等。Nafion修饰电极测定电活性阳离子药物如多巴胺(DA^+)、去甲肾上腺素(NE^+),异丙嗪(PM^+)等已有报道。将DA^+加到电解质溶液中,非电活性阳离子VR^+与电活性的DA^+在Nafion膜上竞争分配,使DA^+的峰电流降低,峰电流的降低与VR^+的浓度对数(在5×10^(-7)～1×10^(-5)mol/L范围内)呈良好的线性关系,以此测定VR^+获得满意的结果。

Verapamil is an electroinactive cationic drug. This paper describes the method for determination of trace verapamil on the Nafion-modified glassy carbon electrode. The peak current of dopamine is decreased when verapamil is added to an electrolyte solution containing electroactive dopamine. A good linear relationship was found between the extent of the decrease in the peak current and the logarithmic concentration of verapamil in the range of 5×10^(-7)～1×10^(-5)mol/L. The detection limit of the method was 2. 5×10^(-7)mol/L. The recovery was 96.2～105. 7%, and the relative standard deviation was 3. 2% (n=10).